Organophosphate poisoning

Organophosphate poisoning

-Acetylcholine esterase inhibitor -> inc Ach level at the synapses

Signs/Symps:

-increased secretions: lacrimation, salivation, pulmonary edema -> crepitation
-bronchospasm -> wheeze
-pinpoint pupils
-decreased level of consciousness


Dx:

-Atropine trial: poisoned pt show little/no anticholinergic effect. (Look at heart rate (inc), skin dryness, pupil dilatation)

-plasma cholinesterase measurement

-others: ecg, bld gas, CXR

Rx:

- Resus + supportive care: IV + airway + ventilation
- Decontamination ( discard clothes, wash skin, stomach contents aspirated if airway is protected )
- Atropine:
(atropine : 2 mg intravenously initially, followed by double doses (e.g., 4 mg, 8 mg, 16 mg, etc.) every 5 minutes until secretions are controlled. Atropine requirements are extremely variable; daily doses range between 10 and 1000 mg or more.)


{간단히
눈 - constricted pupil, lacrimation
입 - salivation
폐 - pulmonary edema (crepitation), bronchospalsm ( wheeze )
심장 - bradycardia}