Sickle cell anemia

Sickle cell anemia
==================

Symp/Sign:
------------
Vaso-occlusive pain: (of chest, abdo,  bone(avascular necrosis esp. femeur head) )
Dactylitis (sausage fingers), swollen dorsa of hands and feet

Fever
Pallor
Jaundice
Splenomegaly
Pneumonia-like sydnrome

Tachycardia
Tachypnoea

Dx:
--------------
DNA analysis
Electrophoresis
Peripheral smear
etc..

Rx:
--------------
Vaso-occlusive crisis:

(1st)
Analgesic
Oxygen

(adjunct)
Transfusion
Antibiotics
Hydration

Chronic

(adjunct)
Hydroxyurea (dec painful crisis)