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2024년 7월 22일 월요일

● 옆구리로 내려가는 인접한 두 신경:

 long thoracic nerve (장흉 신경) <앞쪽에 위치>

 thoracodorsal nerve (흉배 신경)


● 공급

장흉 신경 - 전거근을 공급

흉배 신경 - 광배근을 공급





2024년 7월 16일 화요일

견갑골 내측을 주행하는 2개의 신경

● 견갑골 내측을 따라 주행하는 신경이 2개 있다.

1. accessory nerve (의 plexus) [부신경]

2. dorsal scapular nerve [견갑배신경]


● 

 accessory nerve - 더 표면적이다.

 dorsal scapular nerve - 더 깊다.


 승모근 layer 밑으로 accessory nerve 가 주행하고

 능형근 layer 밑으로 dorsal sacpular nerve 가 주행한다.


 accessory nerve 는 승모근을 신경공급하고

 dorsal scapular nerve 는 능형근을 신경공급한다.




2014년 12월 9일 화요일

파상풍 백신과 파상풍 면역글로불린의 동시투여가 파상풍항체의 미치는 영향좀 알려주세요 감사합니다.

1년도 더 된 구지님의 질문이었습니다..

예방접종 공부하다가 드디어 답을 찾았네요.

예방접종 도우미 홈페이지 pdf 파일
2013년 5월 예방접종 대상 감염병의 역학과 관리(제4판 수정판)
chapter 2 에 나오는 내용입니다.

"1) 불활성화 백신
일반적으로 불활성화 백신의 항원은 혈중의 항체에 의해서 영향을 받지 않기 때문에 항체 함유제제 투여 시기와 상관없이 불활성화 백신 접종이 가능하다. 특히, B형간염 바이러스, 공수병 및 파상풍과 같은 질환에 대한 노출 후 예방 (postexposure prophylaxis)을 위해서는 면역글로불린형태의 항체 제형과 백신을 동시에 투여하는 것이 추천된다.

2) 주사용 약독화 생백신
생백신은 적절한 면역반응을 만들기 위해 인체 내 증식(replication) 과정이 반드시 필요하다. 생백신에 포함된 항원에 대한 항체가 혈중에 있을 때에는 백신 접종 후 증식 과정에 간섭을 받을 수 있다."

요약하면 님께서 생각하는 항체가 항원에 붙어 면역반응이 일어나지 않는다는 논리는 생백신에는 적용이 됩니다. 하지만,
사백신 (바이러스 또는 세균의 전체 또는 일부 분획으로 구성되어 있고, 병원체를 배양한 후 열이나 화학 약품(주로 포르말린을 사용)으로 불활성화 시킨 백신) 은 항체에 의해 영향을 받지 않기 때문에,
모체항체가 아직 남아있는 몇개월 되지 않은 소아에서도 백신을 주기 시작하는 거죠. (예방접종 일정표 참조).
같은 이유로 항체형태의 면역글로불린과 항원형태의 백신의 동시 투여가 가능 합니다.

--
그치만 여기서 해답을 찾지 못한 의문점이 하나 생기긴 하네요.
MMR 생백신 은 생후 12 개월에 주니까 납득이 가는데
같은 생백신인 Polio 는 2,4,6 개월에 효과가 있다는게 이상합니다.

그래서 다시 여기 저기 읽어보고 곰곰히 생각해 보니

"(폴리오 -)  전파양식은 인간에게서 인간으로의 직접감염, 특히 분변-경구 경로로
감염된다.  "


"3) 경구용 또는 비강 투여 약독화 생백신
경구용 장티푸스(typhoid) 백신 및 약독화 인플루엔자 생백신, 로타바이러스 생백신은 항체 함유제제에 의한 증식에 영향을 받지 않으므로 항체 함유제제와 접종 간격에 제한을 받지 않는다."


경구를 통해 감염되는 질병은 IgA 항체의 생성을 통해 예방됨으로...
그리고 IgA 는 태반을 통과하지 못하므로 산모에게서 태아로 면역이 이전되지 않기 때문에
2,4,6 개월에 주는 게 아닐까.. 라는 생각이 듭니다.

--

아.. 또..참고로, 우리나라에선 경구용 폴리오 생백신을 안쓰는구나..
"경구용 폴리오 백신은 더 이상 국내에서 사용되고 있지 않다." (2013)

2014년 6월 9일 월요일

[자문자답] ulnar claw 의 병리기전


ulnar 신경에 병변이 있을 경우


지간 관절을 신전하는 일단 가측 2개의 lubmrical 근육이 작동하지 않기 때문이라는데..


멀쩡한 radial 신경이 지배하는 extensor digitorum 근육도 지간관절을 신전할 수 있다면


왜 clawing 이 생기는 걸까요?





<(내가 생각하는) 답>

그림 참조

-그림에서 녹색선은 근육 또는 힘줄임.

- 빨간 선은?

interphalangeal joint 는 0 도 를 넘어 dorsal 측으로 신전할 수 없고 volar 측으로만 약 90도까지 굴곡할 수 있다는 걸 나타내기 위해

그림에서 PIP joint 를 둥근 톱니바퀴 처럼 표현하고 연결부분에 뒤쪽에 판을 대어 0 도를 넘는 신전을 하지 못하는 걸 나타내었음.

그러니까 빨간선은 0도를 넘지 못하게 하는 판을 표현함.

주의: MP joint 에서는 어느정도 0도를 넘어 dorsal 측으로 신전가능함.


그림설명:

Distal phalanx (및 Middle phalanx) 에 삽입하는 extensor digitorum 은
MP joint 의 신전을 일으킴으로서,
힘줄의 방향에 따라 Interphalangeal joint 의 굴곡이 생기게 끔 한다. -> clawing

Intrinsic muscle 은 각각에 따로 작용하나부다(?) -> no clawing

그러므로 intrinsic muscle 이 작동하지 않으면 extensor muscle 이 작동해도 clawing 이 생긴다.

2014년 5월 17일 토요일

Finasteride 적응증의 모순

남성형 탈모의 치료에 사용되는 약 중 하나:
 finasteride

다낭난소증후군에서 다모증(hirsutism)의 치료로 사용되는 약물 중 하나:
 finasteride

다모와 탈모를 한방에~
FINASTERIDE !!

2014년 1월 15일 수요일

When to stop antithyroid drugs before giving radioactive iodine ablation therapy

When to stop antithyroid drugs before giving radioactive iodine ablation therapy:

- Carbimazole must be stopped 3 to 5 days before ablation therapy.

- Propylthiouracil must be stopped 2 weeks before ablation therapy.


Reference:

European Journal of Endocrinology (2002) 147 1–11

"On the basis, largely, of retrospective data, it appears that carbimazole (or ethimazole), if stopped 3–5 days before treatment, does not influence the outcome of 131I radioactive iodine) therapy. Simultaneous thyrostatic medication most probably reduces the efficacy of 131I, as does restarting it within 7 days. Propylthiouracil seems to have a more prolonged radioprotective effect than carbimazole.

"It only became similar to those treated with 131I alone if more than 15 days had elapsed between the last dose of antithyroid drug(propylthiouracil) and administration of 131I (47)."

2013년 10월 26일 토요일

Nipple discharge

Clinical feature of pathological and physiological nipple discharge.

-Bloody or serous? ( 피가 있나 )

-spontaneous or non-spontaneous? ( 유방에 자극을 줘서 표출한것인가 )

-Single duct or multiple duct? ( 표출했을때 분비물이 여러 구멍에서 나오는가 )

Features of pathological nipple discharge:
Bloody, spontaneous, single duct discharge

Mem tip:
A: Once, again. You're reaching the end of the year without a girlfriend.
B: I'm "bloody spontaenolsly single" man.

Investigations in nipple discharge:
Subareolar U/S or Mammogram -> if normal then ductogram

if any abnormality of one or more of the above -> biopsy

if all normal chance of malignancy less than 3 %. Then follow up pt.

------------------------------------------------------------------------------

"Nipple discharge alone is not usually a sign of breast cancer. Occult malignancy is rare. A period of ‘watchful waiting’ may prevent

patients undergoing unnecessary surgery.
Patients who underwent operation for nipple discharge at a district general hospital (population 460,000) over a 3-year period were

included. All had normal clinical, radiological and cytological examination. Operation and histopathology reports were reviewed.
Eighty-six patients underwent operation for nipple discharge.
Two patients had occult malignancy – DCIS (1) and LCIS (1). No invasive cancer was found."

-<Ann R Coll Surg Engl. 2007 March; 89(2): 124–126.>

"While bloody discharge is more classically associated with a neoplasm, it may also be related to an intra-ductal papilloma."

-<BMJ Best Practice>

"Paget's disease always involvees the nipple and only involves areola as secondary event,
whereas eczema involves the areola and only secondarily affects the nipple."

-<Garden - Surgery textbook>

2013년 8월 20일 화요일

Elbow subluxation

(http://emedicine.medscape.com/article/104158-overview#a01)

Elbow subluxation
==================

Hx:
-Child usually between 2 to 6 years
-pulled arm

Clinical picture:
-The affected arm is held semi flexed, adducted, and pronated.



Mx:

Swelling & tenderness -> rule out fracture with X-ray
(No significant edema or effusion should be found on clinical examination.
If focal swelling or other areas of tenderness are present, radiographs should be performed)


1. supination technique.



2. hyperpronation technique


2013년 7월 26일 금요일

Pupil and toxicology

Pupil and toxicology
===================

Dilated pupil:

-anticholinergic (e.g.  atropine, tricyclic antidepressant ) <BP will be lower>
-adrenergic (e.g. cocaine, amphetamine) <BP will be higher>

Constricted pupil:

-cholinergic (e.g. organophosphate poisoning) <antidote: atropine>
-opioids (e.g. morphine, heroin)  <antidote: naloxone>

2013년 7월 15일 월요일

Brain tumor headache

Characteristics of headache suggestive of brain tumor.
=========================================================

{summary

온 onset - at early morning or at night

듀 duration -  if duration of isolated headache  > 10 weeks - brain tumor unlikely.

로 location - may mimic migraine or tension headache

캐 "new" , "menigism" (아래참조)

프 precipitant - worse on exercise / valsalva (couhging / sneezing / bending over)

(래)

(리)

others:
"new"
-New - different (pattern) from previous headache
-New after age 50
-headache in children and elderly

-progressive

"like meningitis"
-with new neurologic signs (including seizure)
-with neck stiffness
-with fever
}


Though headache is a common symptom of brain tumor, it is infrequently seen in isolation. In the majority of cases, brain tumor

headache is associated with other neurologic symptoms such as seizures or focal weakness.

Isolated headache of more than 10 weeks duration is seldom caused by brain tumor.

The classic "brain tumor triad," comprising nocturnal or early morning occurrence, nausea/vomiting, and severe nature, has not

been borne out as a typical pattern in modern studies. In one series of 53 adults with brain tumor headache, this triad occurred in

only nine patients (17 percent).


Headache in brain tumor may mimic migraine and tension headache.
The headache related to brain tumor was described as similar to tension-type headache in 41 patients (77 percent), similar to

migraine (although with atypical features) in five patients (9 percent), and was unclassifiable in seven patients (13 percent).


Because of the variable nature of headache among patients with brain tumor, the diagnosis of headache attributed to brain tumor

should be considered in patients who complain of a headache with any of the following "red flags" [40]:

    Acute, new, usually severe headache or headache that has changed from previous patterns
    New headache onset in an adult, especially over 50 years of age
    Headache in the elderly or in children
    Headache on exertion, onset at night, or onset at early morning
    Headache that is progressive in nature
    Headache associated with fever or other systemic symptoms
    Headache with meningismus
    Headache with new neurologic signs
    Precipitation of head pain with the Valsalva maneuver (by coughing, sneezing, or bending over)


Reference:
- Brain tumor headache (UPTODATE) Christine L Lay, MD, FRCPC; Christina Sun, MD

2013년 7월 10일 수요일

Malaria

Malaria
===================

Symp/Sign:
-------------

(common)
Fever
(hemolysis:)
Pallor
Hepatosplenomegaly

(uncommon)
Jaundice
Anuria
Abdominal pain
Nausea vomiting
Arthralgia
Altered level of consciousness

{외우기 팁

Fever (당연)
Hemolysis.
Organs affected (Liver, spleen, kidney, brain)

혈색소가 파괴된다
- 어디에서 파괴되니? - spleen -> hepatosplenomegaly
- 혈색소 부족 -> pallor
- 혈색소는 어떻게 됬니? ->  jaundice 발생
옆에있던 kidney failure -> anuria
liver 가 megaly 라 아픔 -> abdominal pain
abdo pain 이니까 -> nausea vomiting.
}


Dx:
-------------
Blood smear / Giemsa-stain

Detection of parasite antigen or enzymes

Sickle cell anemia

Sickle cell anemia
==================

Symp/Sign:
------------
Vaso-occlusive pain: (of chest, abdo,  bone(avascular necrosis esp. femeur head) )
Dactylitis (sausage fingers), swollen dorsa of hands and feet

Fever
Pallor
Jaundice
Splenomegaly
Pneumonia-like sydnrome

Tachycardia
Tachypnoea




Dx:
--------------
DNA analysis
Electrophoresis
Peripheral smear
etc..

Rx:
--------------
Vaso-occlusive crisis:

(1st)
Analgesic
Oxygen

(adjunct)
Transfusion
Antibiotics
Hydration

Chronic

(adjunct)
Hydroxyurea (dec painful crisis)

2013년 6월 26일 수요일

Stroke

Stroke

Classified into two types:

1) Ischaemic

2) haemorrhagic


Ischamic stroke:
=====================
is either - thrombotic or embolic

thrombotic - from ahterosclerosis

embolic - from heart or from aneurysm

Symp:
----------------
monocular vision loss, visual field loss
unilateral (facial/limb) weakness
aphasia (impaired language function - sign of dominant hemispheric ischaemia)
ataxia
{symp mem tip below}

Test:
----------------
CT brain (mainly to exclude hemorrhagic stroke. CT brain may be normal within first few hours of ischaemic stroke.


Rx:
----------------
presentation within 3 hrs and no contraindication to thrombolytics -> tPA (ateplase)
presentation after 3 hrs -> aspirin 300 mg dly

cerebral venous sinus thrombosis -> heparin / warfarin

DVT prophylaxis


haemorrhagic stroke
=====================

Symp:
----------------
Headache ("most severe headache of my life" suggests subarachnoid haemorrahge)
Neck stiffness
Visual impairment (hemianopia(half visual field defect), diplopia), photophobia
Unilateral (face/limb) weakness
Seonsory loss
Aphasia (impaired language function - sign of dominant hemispheric ischaemia)
Dysarthria, ataxia
Nausea/vomiting (uncommon)
Altered level of consciousness/confusion (uncommon)
{symp mem tip below}

Test:
----------------
CT brain
INR


Rx:
----------------
-Airway protection (Intubate if GCS <= 8)
-Sedation (with propofol/midazolam/barbiturate - e.g. in ICU setting - midazolam 0.1 mg/kg (typically 5 mg) ivi as a loading dose,

then 0.1 mg/kg/hr)
-Anticonvulsant (phenytoin 15 mg/kg over 20 min loading, then 3 mg/kg 12hrly)
-Antipyretic (paracetamol)
-BP control ( pt often have sys BP > 180. keep sys BP just below 160 using labetalol. CAUTION - too low BP may worsen the

damage)
-Treat hyperglycemia (if serum glucose > 10 mmol/L)
-Head 30 degree elevated at bed.
-Mannitol 1g/kg IV bolus, maintenance 0.25 ~ 0.5 g /kg every 6 hrs.
-Correct coagulopathy if it exists.

Neurosurg consult

{mem tip:
Airway, Sedation, -ABC
Head 30 degree, mannitol, -압력 낮춰 공급높이고
Hypertension, Diabetes, Epilepsy  -대사활동 줄여 소모줄이고
}

{symp mem tip:

//////////////
Cincinnati prehospital stroke scale:
==================================

- Facial drop (seen by asking the pt to - "show me your teeth")
- Arm drift ( hold out two arms with palms up and eyes closed for 10 sec. one arm drifts down)
- Abnormal speech ( have the pt say "you can't teach an old dog new tricks" - pt slurs words/uses wrong words/can't speak)

if one of the above positive - 75 % chance of stroke
if all three positive - more than 85 % chance of stroke
/////////////


stroke (both hemorrhagic & ischaemic) - cincinnati scale 에 시력/시야 검사 더함.

Visual impairment:
-ischaemic stroke: monocular blindness, visual field defect
-hemorrhagic stroke: hemianopia(half visual field defect), diplopia

Hemorrhagic stroke 에는 다음과 같은 특징이 더함.

Characteristic of hemorrhagic stroke:
-Headahce (common but may be absent)
-Neck stiffness (common)
-nausea/vomiting (uncommon)
-altered level of consciousness (uncommon)
즉,
마치 memnigitis 같이 - neck stiffness, headache, nausea vomitting
바보같은 radiologist 는 GCS 15/15 은 hemorrhage 아니라고 하겠지만 hemorrhagic stroke 가 꼭 혼수상태일 필욘 없음.
다만 GCS 가 낮으면 mortality 가 높아짐. Haemorrhage size 가 커도 mortality 높아짐

Neuroleptic malignant syndrome

Neuroleptic malignant syndrome
===============================

Hx:
-----------
Exposure to antipsychotic medications,
Abrupt withdrawal of dopaminergic drugs, and
Structural brain abnormality.

Symp:
-----------
Altered mental status (confusion, psychosis, delirium)
Muscle rigidity (lead pipe or generalized hypertonia)
Hypertension, hypotension, tachycardia
Diaphoresis, sialorrhoea, urinary incontinence
Fever

{mem tip
머리가 굳고 (altered mental status)
몸이 굳는다 (rigidity)
몸이 굳어 혈압 상승. 몸이 굳어 열이남.
여러군데서 물이 샘 (diaphresis - 땀, sialorrhea - 침, urinary continence - 오줌)
}

Test:
-----------
elevated CK (>500 units/L)
Other metabolic panel often normal.

Rx:
-----------
Stop antipsychotic, dopaminergic antagonist. Restart/continue dopamine agonist.
rhabdomyolysis - vigorous hydration with IV fluid
Hyperthemia - paracetamol / ibprofen

dantrolene(controversial, may prolong clinical recovery) 1mg/kg IVI once. (over 1 hr)

2013년 6월 24일 월요일

Testicular torsion / Epididymitis

Three main differential Dx of painful testis: Testicular torsion, epididymitis, orchitis

Testicular torsion:
==================

Symp:
-----------------------
High riding testicle
{mem tip: 말려 올라갔으니까}

No pain relief upon elevation of scrotum
{mem tip: 벌써 올라가있으니까 - 내가 올려본다}
(if pt experience pain relief with elevation of the testis (Prehn sign) -> suggests epididymitis more than torsion)

Absent cremasteric reflex(elevation of the testis in response to stroking of the upper inner thigh)
(it also may be absent in boys without torsion, particularly if they are younger than six months)
{mem tip: 벌써 올라가있으니까 - 환자의 근육이 올린다}

The testis may be lying horizontally, displacing the epididymis from its normal posterolateral position.

Scrotal swelling/edema

Nausea vomiting
(Nearly 90 percent of patients may have associated nausea and vomiting)


Dx:
-----------------------
Scrotal ultrasound (Collour doppler)

Abnormal urinalysis suggests epididymitis/orchitis more than testicular torsion

Rx:
-----------------------
- Analgesia

- immediate urological consultation for emergency scrotal exploration

   Typical rates of viability:
   * Detorsion within 4 to 6 hours — 100 percent viability
   * Detorsion after 12 hours — 20 percent viability
   * Detorsion after 24 hours — 0 percent viability


- if surgery is not available within 6 hours [13] or while preparations for surgery are being made -> manual de-torsion

Manual de-torsion is a temporising measure. The technique involves rotating the right testicle counter-clockwise and the left testicle

clockwise. In other words, the affected testicle is rotated as if opening a book, hence the 'open book' method.



Epididymitis
===================

Symps
--------------
Pain and swelling typically develops over the course of a few days (unlike testicular torsion, which is usually of sudden onset).

The affected testis has a normal vertical lie

Pt may experience pain relief with elevation of the testis (Prehn sign)

Painful micturition (uncommon)

urethral discharge (uncommon)

Epididymitis is caused by organisms causing UTI/STI.


Rx:
--------------
Sexually transmitted:
-cetriaxone 250 mg IMI stat AND
-doxycycline 100 mg BD PO for 14 days
(NOTE: Doxycycline is not approved for use in children younger than the age of eight years)

Not sexually transmitted:
-empiric quinolone: ofloxacin 300 mg BD PO for 10 days OR levofloxacin 500 mg dly PO for 10 days
(NOTE:  Fluoroquinolones are not approved for use in patients younger than 18 years of age when other effective alternatives are available)

Prog
--------------
Swelling of testis from epididymitis may takes a month or more to subside

2013년 6월 22일 토요일

Pre-eclampsia

Pre-ecampsia:

Def:
----------------
Hypertension ( sys BP > 140 and/or dia BP > 90 ) with
Proteinuria ( urinary protein > 0.3 g/ 24hr or 1+ protein on urine dipstix )
that develops after 20 wks gestational age.

Classification:
----------------
mild to moderate:
-sys BP 140~160, and/or, dia BP 90~110

severe:
one of the following:

-sys BP > 160, and/or, dia BP > 110

-proteinuria > 5g/24hrs or >= 3+ on urine dipstix

-Oliguria <500 mL/24 hours

-Cerebral or visual disturbances

-Pulmonary oedema or cyanosis

-Epigastric or right upper quadrant pain

-Impaired liver function

-Thrombocytopenia

-Fetal growth restriction.

{간단히보면  BP, proteinuria, HELLP synrome sign, fetus 중에 하나 이상, 요렇게 보자}

Symps/signs:
----------------
Danger signs:
-severe or persistent headache, nausea or vomiting, visual changes(blurry vision)<suggesting cerebral pathology/hemorrhage>,
-shortness of breath<suggesting pulmonary edema>,
-right upper quadrant or epigastric pain <suggesting liver hemorrhage>or
-decreased urine output <suggesting renal failure>

Dx
----------------
do FBC, UE, AST;ALT (to pick up HELLP syndrome : HE(hemolysis - low Hb) L (deranged liver enzyme) LP (low platelete) syndrome)
fetal ultrasound

Mx
----------------

Severe preeclampsia:
Think 4 things: hypertension, seizure, organ dysfunction, fetus

* hypertension -> IV fluid, labetalol/methyldopa
* seizure -> magnesium sulphate
* organdysfunction-> delivery
* fetus-> betamethasone and delivery


{mem tip
(피하시오) -> 피-fetus, 하-hypertension, 시-seizure, 오-organ dysfunction)

Rx 순서: seziure -> HT
씨~~~~이~~ 하!
}


1) prevent/treat seizure:
- Magnesium sulphate: 4 g in 200ml normal saline IVI over 20 mintues + 10 g IM statI
- followed by 5 g IMI every 4 hrs for 24 hrs.

#just good to know:
(MgSO4 has shown benefit in established seizures but its  role in prevention of seizures is uncertain.)
#watch out for toxicity:
(progression of clinical pictures in MgSO4 toxicity with increasing MgSO4 serum level:
loss of tendon reflex -> respiratory paralysis -> cardiac arrest )

2) IV maintenance fluid:
- 300 ml R/L IV stat
(if giving magnesium sulphate in 200 ml normal saline, give 100 ml Ringers Lactate instead of 300 ml because the two adds up to be 300 ml in total (200ml NS + 100ml R/L)
- then continue maintenance fluid: 80 mL/hour

3) Treat Hypertension:
-IV Labetalol:
(20 mg - 40 mg - 80 mg - 80 mg (at 10 minute intervals until desired response)
max dose: 220 mg in total.)
#Goal BP: <150 / 100

-Methyldopa 500 mg tds PO

4) Mature the fetal lung:
-Betamethasone 12 mg IM 12 hrly (give total of 2 doses)

5) reverse organ dysfunction
-Deliver the baby

2013년 6월 20일 목요일

Corticosteroid

Giving corticosteroid
====================

Suppressive action of corticosteroid on cortisol secretion is least when it is given as a SINGLE dose in the MORNING.
(Therefore, give corticosteriod in the morning as a single dose and not at night)

/////////
HPA(hypothalamic-pituitary-adrenal axis) suppression likely ? Patients who have received glucocorticoids who meet the following

criteria are presumed to have HPA suppression:

    -Anyone who has received a glucocorticoid dose comparable to more than 20 mg of prednisone a day for more than three weeks.
    -Anyone who has received an evening/bedtime dose of prednisone for more than a few weeks.
    -Any patient who has a Cushingoid appearance
///////

///////
Tapering regimen

    10 mg/day every one to two weeks at an initial dose above 60 mg of prednisone or equivalent per day.
    5 mg/day every one to two weeks at prednisone doses between 60 and 20 mg/day.
    2.5 mg/day every one to two weeks at prednisone doses between 19 and 10 mg/day.
    1 mg/day every one to two weeks at prednisone doses between 9 and 5 mg/day.
    0.5 mg/day every one to two weeks at prednisone doses below 5 mg/day. This can be achieved by alternating daily doses, eg, 5

mg on day 1 and 4 mg on day 2. (i.e. 1 mg/ every 2 days)

[..-60-20-10-5-..]
[10-5-2.5-1-0.5]
////////

signs of adrenal insufficiency:
----------------------------
shock
non-specific malaise

side effect of corticosteroid
---------------------------
mem tip: 오잉 (내가 왜) 고혈압에 당뇨지?

-osteoporosis
-infection
-hypertension
-hyperglycemia