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2013년 10월 26일 토요일

Nipple discharge

Clinical feature of pathological and physiological nipple discharge.

-Bloody or serous? ( 피가 있나 )

-spontaneous or non-spontaneous? ( 유방에 자극을 줘서 표출한것인가 )

-Single duct or multiple duct? ( 표출했을때 분비물이 여러 구멍에서 나오는가 )

Features of pathological nipple discharge:
Bloody, spontaneous, single duct discharge

Mem tip:
A: Once, again. You're reaching the end of the year without a girlfriend.
B: I'm "bloody spontaenolsly single" man.

Investigations in nipple discharge:
Subareolar U/S or Mammogram -> if normal then ductogram

if any abnormality of one or more of the above -> biopsy

if all normal chance of malignancy less than 3 %. Then follow up pt.

------------------------------------------------------------------------------

"Nipple discharge alone is not usually a sign of breast cancer. Occult malignancy is rare. A period of ‘watchful waiting’ may prevent

patients undergoing unnecessary surgery.
Patients who underwent operation for nipple discharge at a district general hospital (population 460,000) over a 3-year period were

included. All had normal clinical, radiological and cytological examination. Operation and histopathology reports were reviewed.
Eighty-six patients underwent operation for nipple discharge.
Two patients had occult malignancy – DCIS (1) and LCIS (1). No invasive cancer was found."

-<Ann R Coll Surg Engl. 2007 March; 89(2): 124–126.>

"While bloody discharge is more classically associated with a neoplasm, it may also be related to an intra-ductal papilloma."

-<BMJ Best Practice>

"Paget's disease always involvees the nipple and only involves areola as secondary event,
whereas eczema involves the areola and only secondarily affects the nipple."

-<Garden - Surgery textbook>

2013년 8월 20일 화요일

Elbow subluxation

(http://emedicine.medscape.com/article/104158-overview#a01)

Elbow subluxation
==================

Hx:
-Child usually between 2 to 6 years
-pulled arm

Clinical picture:
-The affected arm is held semi flexed, adducted, and pronated.



Mx:

Swelling & tenderness -> rule out fracture with X-ray
(No significant edema or effusion should be found on clinical examination.
If focal swelling or other areas of tenderness are present, radiographs should be performed)


1. supination technique.



2. hyperpronation technique


2013년 7월 26일 금요일

Pupil and toxicology

Pupil and toxicology
===================

Dilated pupil:

-anticholinergic (e.g.  atropine, tricyclic antidepressant ) <BP will be lower>
-adrenergic (e.g. cocaine, amphetamine) <BP will be higher>

Constricted pupil:

-cholinergic (e.g. organophosphate poisoning) <antidote: atropine>
-opioids (e.g. morphine, heroin)  <antidote: naloxone>

2013년 7월 15일 월요일

Brain tumor headache

Characteristics of headache suggestive of brain tumor.
=========================================================

{summary

온 onset - at early morning or at night

듀 duration -  if duration of isolated headache  > 10 weeks - brain tumor unlikely.

로 location - may mimic migraine or tension headache

캐 "new" , "menigism" (아래참조)

프 precipitant - worse on exercise / valsalva (couhging / sneezing / bending over)

(래)

(리)

others:
"new"
-New - different (pattern) from previous headache
-New after age 50
-headache in children and elderly

-progressive

"like meningitis"
-with new neurologic signs (including seizure)
-with neck stiffness
-with fever
}


Though headache is a common symptom of brain tumor, it is infrequently seen in isolation. In the majority of cases, brain tumor

headache is associated with other neurologic symptoms such as seizures or focal weakness.

Isolated headache of more than 10 weeks duration is seldom caused by brain tumor.

The classic "brain tumor triad," comprising nocturnal or early morning occurrence, nausea/vomiting, and severe nature, has not

been borne out as a typical pattern in modern studies. In one series of 53 adults with brain tumor headache, this triad occurred in

only nine patients (17 percent).


Headache in brain tumor may mimic migraine and tension headache.
The headache related to brain tumor was described as similar to tension-type headache in 41 patients (77 percent), similar to

migraine (although with atypical features) in five patients (9 percent), and was unclassifiable in seven patients (13 percent).


Because of the variable nature of headache among patients with brain tumor, the diagnosis of headache attributed to brain tumor

should be considered in patients who complain of a headache with any of the following "red flags" [40]:

    Acute, new, usually severe headache or headache that has changed from previous patterns
    New headache onset in an adult, especially over 50 years of age
    Headache in the elderly or in children
    Headache on exertion, onset at night, or onset at early morning
    Headache that is progressive in nature
    Headache associated with fever or other systemic symptoms
    Headache with meningismus
    Headache with new neurologic signs
    Precipitation of head pain with the Valsalva maneuver (by coughing, sneezing, or bending over)


Reference:
- Brain tumor headache (UPTODATE) Christine L Lay, MD, FRCPC; Christina Sun, MD

2013년 7월 10일 수요일

Malaria

Malaria
===================

Symp/Sign:
-------------

(common)
Fever
(hemolysis:)
Pallor
Hepatosplenomegaly

(uncommon)
Jaundice
Anuria
Abdominal pain
Nausea vomiting
Arthralgia
Altered level of consciousness

{외우기 팁

Fever (당연)
Hemolysis.
Organs affected (Liver, spleen, kidney, brain)

혈색소가 파괴된다
- 어디에서 파괴되니? - spleen -> hepatosplenomegaly
- 혈색소 부족 -> pallor
- 혈색소는 어떻게 됬니? ->  jaundice 발생
옆에있던 kidney failure -> anuria
liver 가 megaly 라 아픔 -> abdominal pain
abdo pain 이니까 -> nausea vomiting.
}


Dx:
-------------
Blood smear / Giemsa-stain

Detection of parasite antigen or enzymes

Sickle cell anemia

Sickle cell anemia
==================

Symp/Sign:
------------
Vaso-occlusive pain: (of chest, abdo,  bone(avascular necrosis esp. femeur head) )
Dactylitis (sausage fingers), swollen dorsa of hands and feet

Fever
Pallor
Jaundice
Splenomegaly
Pneumonia-like sydnrome

Tachycardia
Tachypnoea




Dx:
--------------
DNA analysis
Electrophoresis
Peripheral smear
etc..

Rx:
--------------
Vaso-occlusive crisis:

(1st)
Analgesic
Oxygen

(adjunct)
Transfusion
Antibiotics
Hydration

Chronic

(adjunct)
Hydroxyurea (dec painful crisis)

2013년 6월 26일 수요일

Stroke

Stroke

Classified into two types:

1) Ischaemic

2) haemorrhagic


Ischamic stroke:
=====================
is either - thrombotic or embolic

thrombotic - from ahterosclerosis

embolic - from heart or from aneurysm

Symp:
----------------
monocular vision loss, visual field loss
unilateral (facial/limb) weakness
aphasia (impaired language function - sign of dominant hemispheric ischaemia)
ataxia
{symp mem tip below}

Test:
----------------
CT brain (mainly to exclude hemorrhagic stroke. CT brain may be normal within first few hours of ischaemic stroke.


Rx:
----------------
presentation within 3 hrs and no contraindication to thrombolytics -> tPA (ateplase)
presentation after 3 hrs -> aspirin 300 mg dly

cerebral venous sinus thrombosis -> heparin / warfarin

DVT prophylaxis


haemorrhagic stroke
=====================

Symp:
----------------
Headache ("most severe headache of my life" suggests subarachnoid haemorrahge)
Neck stiffness
Visual impairment (hemianopia(half visual field defect), diplopia), photophobia
Unilateral (face/limb) weakness
Seonsory loss
Aphasia (impaired language function - sign of dominant hemispheric ischaemia)
Dysarthria, ataxia
Nausea/vomiting (uncommon)
Altered level of consciousness/confusion (uncommon)
{symp mem tip below}

Test:
----------------
CT brain
INR


Rx:
----------------
-Airway protection (Intubate if GCS <= 8)
-Sedation (with propofol/midazolam/barbiturate - e.g. in ICU setting - midazolam 0.1 mg/kg (typically 5 mg) ivi as a loading dose,

then 0.1 mg/kg/hr)
-Anticonvulsant (phenytoin 15 mg/kg over 20 min loading, then 3 mg/kg 12hrly)
-Antipyretic (paracetamol)
-BP control ( pt often have sys BP > 180. keep sys BP just below 160 using labetalol. CAUTION - too low BP may worsen the

damage)
-Treat hyperglycemia (if serum glucose > 10 mmol/L)
-Head 30 degree elevated at bed.
-Mannitol 1g/kg IV bolus, maintenance 0.25 ~ 0.5 g /kg every 6 hrs.
-Correct coagulopathy if it exists.

Neurosurg consult

{mem tip:
Airway, Sedation, -ABC
Head 30 degree, mannitol, -압력 낮춰 공급높이고
Hypertension, Diabetes, Epilepsy  -대사활동 줄여 소모줄이고
}

{symp mem tip:

//////////////
Cincinnati prehospital stroke scale:
==================================

- Facial drop (seen by asking the pt to - "show me your teeth")
- Arm drift ( hold out two arms with palms up and eyes closed for 10 sec. one arm drifts down)
- Abnormal speech ( have the pt say "you can't teach an old dog new tricks" - pt slurs words/uses wrong words/can't speak)

if one of the above positive - 75 % chance of stroke
if all three positive - more than 85 % chance of stroke
/////////////


stroke (both hemorrhagic & ischaemic) - cincinnati scale 에 시력/시야 검사 더함.

Visual impairment:
-ischaemic stroke: monocular blindness, visual field defect
-hemorrhagic stroke: hemianopia(half visual field defect), diplopia

Hemorrhagic stroke 에는 다음과 같은 특징이 더함.

Characteristic of hemorrhagic stroke:
-Headahce (common but may be absent)
-Neck stiffness (common)
-nausea/vomiting (uncommon)
-altered level of consciousness (uncommon)
즉,
마치 memnigitis 같이 - neck stiffness, headache, nausea vomitting
바보같은 radiologist 는 GCS 15/15 은 hemorrhage 아니라고 하겠지만 hemorrhagic stroke 가 꼭 혼수상태일 필욘 없음.
다만 GCS 가 낮으면 mortality 가 높아짐. Haemorrhage size 가 커도 mortality 높아짐

Neuroleptic malignant syndrome

Neuroleptic malignant syndrome
===============================

Hx:
-----------
Exposure to antipsychotic medications,
Abrupt withdrawal of dopaminergic drugs, and
Structural brain abnormality.

Symp:
-----------
Altered mental status (confusion, psychosis, delirium)
Muscle rigidity (lead pipe or generalized hypertonia)
Hypertension, hypotension, tachycardia
Diaphoresis, sialorrhoea, urinary incontinence
Fever

{mem tip
머리가 굳고 (altered mental status)
몸이 굳는다 (rigidity)
몸이 굳어 혈압 상승. 몸이 굳어 열이남.
여러군데서 물이 샘 (diaphresis - 땀, sialorrhea - 침, urinary continence - 오줌)
}

Test:
-----------
elevated CK (>500 units/L)
Other metabolic panel often normal.

Rx:
-----------
Stop antipsychotic, dopaminergic antagonist. Restart/continue dopamine agonist.
rhabdomyolysis - vigorous hydration with IV fluid
Hyperthemia - paracetamol / ibprofen

dantrolene(controversial, may prolong clinical recovery) 1mg/kg IVI once. (over 1 hr)

2013년 6월 24일 월요일

Testicular torsion / Epididymitis

Three main differential Dx of painful testis: Testicular torsion, epididymitis, orchitis

Testicular torsion:
==================

Symp:
-----------------------
High riding testicle
{mem tip: 말려 올라갔으니까}

No pain relief upon elevation of scrotum
{mem tip: 벌써 올라가있으니까 - 내가 올려본다}
(if pt experience pain relief with elevation of the testis (Prehn sign) -> suggests epididymitis more than torsion)

Absent cremasteric reflex(elevation of the testis in response to stroking of the upper inner thigh)
(it also may be absent in boys without torsion, particularly if they are younger than six months)
{mem tip: 벌써 올라가있으니까 - 환자의 근육이 올린다}

The testis may be lying horizontally, displacing the epididymis from its normal posterolateral position.

Scrotal swelling/edema

Nausea vomiting
(Nearly 90 percent of patients may have associated nausea and vomiting)


Dx:
-----------------------
Scrotal ultrasound (Collour doppler)

Abnormal urinalysis suggests epididymitis/orchitis more than testicular torsion

Rx:
-----------------------
- Analgesia

- immediate urological consultation for emergency scrotal exploration

   Typical rates of viability:
   * Detorsion within 4 to 6 hours — 100 percent viability
   * Detorsion after 12 hours — 20 percent viability
   * Detorsion after 24 hours — 0 percent viability


- if surgery is not available within 6 hours [13] or while preparations for surgery are being made -> manual de-torsion

Manual de-torsion is a temporising measure. The technique involves rotating the right testicle counter-clockwise and the left testicle

clockwise. In other words, the affected testicle is rotated as if opening a book, hence the 'open book' method.



Epididymitis
===================

Symps
--------------
Pain and swelling typically develops over the course of a few days (unlike testicular torsion, which is usually of sudden onset).

The affected testis has a normal vertical lie

Pt may experience pain relief with elevation of the testis (Prehn sign)

Painful micturition (uncommon)

urethral discharge (uncommon)

Epididymitis is caused by organisms causing UTI/STI.


Rx:
--------------
Sexually transmitted:
-cetriaxone 250 mg IMI stat AND
-doxycycline 100 mg BD PO for 14 days
(NOTE: Doxycycline is not approved for use in children younger than the age of eight years)

Not sexually transmitted:
-empiric quinolone: ofloxacin 300 mg BD PO for 10 days OR levofloxacin 500 mg dly PO for 10 days
(NOTE:  Fluoroquinolones are not approved for use in patients younger than 18 years of age when other effective alternatives are available)

Prog
--------------
Swelling of testis from epididymitis may takes a month or more to subside

2013년 6월 22일 토요일

Pre-eclampsia

Pre-ecampsia:

Def:
----------------
Hypertension ( sys BP > 140 and/or dia BP > 90 ) with
Proteinuria ( urinary protein > 0.3 g/ 24hr or 1+ protein on urine dipstix )
that develops after 20 wks gestational age.

Classification:
----------------
mild to moderate:
-sys BP 140~160, and/or, dia BP 90~110

severe:
one of the following:

-sys BP > 160, and/or, dia BP > 110

-proteinuria > 5g/24hrs or >= 3+ on urine dipstix

-Oliguria <500 mL/24 hours

-Cerebral or visual disturbances

-Pulmonary oedema or cyanosis

-Epigastric or right upper quadrant pain

-Impaired liver function

-Thrombocytopenia

-Fetal growth restriction.

{간단히보면  BP, proteinuria, HELLP synrome sign, fetus 중에 하나 이상, 요렇게 보자}

Symps/signs:
----------------
Danger signs:
-severe or persistent headache, nausea or vomiting, visual changes(blurry vision)<suggesting cerebral pathology/hemorrhage>,
-shortness of breath<suggesting pulmonary edema>,
-right upper quadrant or epigastric pain <suggesting liver hemorrhage>or
-decreased urine output <suggesting renal failure>

Dx
----------------
do FBC, UE, AST;ALT (to pick up HELLP syndrome : HE(hemolysis - low Hb) L (deranged liver enzyme) LP (low platelete) syndrome)
fetal ultrasound

Mx
----------------

Severe preeclampsia:
Think 4 things: hypertension, seizure, organ dysfunction, fetus

* hypertension -> IV fluid, labetalol/methyldopa
* seizure -> magnesium sulphate
* organdysfunction-> delivery
* fetus-> betamethasone and delivery


{mem tip
(피하시오) -> 피-fetus, 하-hypertension, 시-seizure, 오-organ dysfunction)

Rx 순서: seziure -> HT
씨~~~~이~~ 하!
}


1) prevent/treat seizure:
- Magnesium sulphate: 4 g in 200ml normal saline IVI over 20 mintues + 10 g IM statI
- followed by 5 g IMI every 4 hrs for 24 hrs.

#just good to know:
(MgSO4 has shown benefit in established seizures but its  role in prevention of seizures is uncertain.)
#watch out for toxicity:
(progression of clinical pictures in MgSO4 toxicity with increasing MgSO4 serum level:
loss of tendon reflex -> respiratory paralysis -> cardiac arrest )

2) IV maintenance fluid:
- 300 ml R/L IV stat
(if giving magnesium sulphate in 200 ml normal saline, give 100 ml Ringers Lactate instead of 300 ml because the two adds up to be 300 ml in total (200ml NS + 100ml R/L)
- then continue maintenance fluid: 80 mL/hour

3) Treat Hypertension:
-IV Labetalol:
(20 mg - 40 mg - 80 mg - 80 mg (at 10 minute intervals until desired response)
max dose: 220 mg in total.)
#Goal BP: <150 / 100

-Methyldopa 500 mg tds PO

4) Mature the fetal lung:
-Betamethasone 12 mg IM 12 hrly (give total of 2 doses)

5) reverse organ dysfunction
-Deliver the baby

2013년 6월 20일 목요일

Corticosteroid

Giving corticosteroid
====================

Suppressive action of corticosteroid on cortisol secretion is least when it is given as a SINGLE dose in the MORNING.
(Therefore, give corticosteriod in the morning as a single dose and not at night)

/////////
HPA(hypothalamic-pituitary-adrenal axis) suppression likely ? Patients who have received glucocorticoids who meet the following

criteria are presumed to have HPA suppression:

    -Anyone who has received a glucocorticoid dose comparable to more than 20 mg of prednisone a day for more than three weeks.
    -Anyone who has received an evening/bedtime dose of prednisone for more than a few weeks.
    -Any patient who has a Cushingoid appearance
///////

///////
Tapering regimen

    10 mg/day every one to two weeks at an initial dose above 60 mg of prednisone or equivalent per day.
    5 mg/day every one to two weeks at prednisone doses between 60 and 20 mg/day.
    2.5 mg/day every one to two weeks at prednisone doses between 19 and 10 mg/day.
    1 mg/day every one to two weeks at prednisone doses between 9 and 5 mg/day.
    0.5 mg/day every one to two weeks at prednisone doses below 5 mg/day. This can be achieved by alternating daily doses, eg, 5

mg on day 1 and 4 mg on day 2. (i.e. 1 mg/ every 2 days)

[..-60-20-10-5-..]
[10-5-2.5-1-0.5]
////////

signs of adrenal insufficiency:
----------------------------
shock
non-specific malaise

side effect of corticosteroid
---------------------------
mem tip: 오잉 (내가 왜) 고혈압에 당뇨지?

-osteoporosis
-infection
-hypertension
-hyperglycemia

Bell's palsy

Bell's palsy
=============


Defi:
---------------
idiopathic
sudden onset
unilateral facial nerve paralysis

typically shows some degree of improval within 4 to 6 months.
If known etiology, or If slowly progressive -> not Bell's palsy

Symp
---------------
Motor: Unilateral paralysis (lower motor neuron involving all branches of facial nerve)
Sensory: Facial pain along the course of the facial nerve
Dry eye

Clinical exam
---------------
ipsilateral conductive loss(sensorineural hearing loss) should be invesitaged for possible middle ear infection/neoplastic lesions

Diff Dx
---------------
Stroke - forehead is spared. other neurological dysfunctions are often present.
Middle ear infection complication
Tumour - ipsilateral hearing loss

mem tip: 스튜오(디스 이름이) Bell.

Rx:
---------------
BMJ BEST PRACTICE -> Predisone 25 mg dly PO for 10 days
UPTODATE -> Prednisone 60 mg dly PO for 7 days + valacyclovir 1g tds PO for 7 days

eye protection - artificial tears, ophthalmic lubricant

Prognosis:
---------------

71 % pts recovers to normal or near normal (24 % recovers to normal)



2013년 6월 17일 월요일

Meniere's disease

Meniere's disease
====================

Meniere's disease - idiopathic {mem tip "D"isease = i"D"iopathic)
Meniere's syndrome - secondary to a cause

Proposed pathogenesis
----------------------
endolymphic hydrops (hydrops: excessive accumulation of serous fluid in tissues or cavities of the body)


Symptoms
--------------------
-Hearing loss (Sensorineural hearing loss is fluctuating and progressive. Vertigo episodes last from 20 minutes to 24 hours, and

typically occur in clusters)
-Tinnitis
-Vertigo (episodic , sudden onset vertigo)
-Sensation of fullness in the affected ear.


-positive Romberg's test (common)
 (Swaying or falling when asked to stand with feet together and eyes closed.)
-positive Fukuda's stepping test (common)
 (Turning towards the affected side when asked to march in place with eyes closed.)
-inability to walk tandem (heel-to-toe) in a straight line (often)

-Sensorineural hearing loss

Dx
--------------------

Meniere's disease is a clinical diagnosis. Although not diagnostic, patients should undergo audiometry, vestibular testing, and MRI

to rule out other causes of symptoms


Rx:
--------------------


all pt
- low salt diet ( < 1500~2000  mg/day )
- triamterene/hydrochlorothiazide : 50/25 mg orally once daily
 or
 acetazolamide : 250 mg orally (regular-release) twice daily

symptomatic vetigo
- promethazine:  12.5 to 25 mg orally/rectally every 4-6 hours when required
- <adjunct> intratympanic injections (dexmethasone)
- <adjunct> Meniett device

tinnitis
- tinnitis masker (Tinnitus maskers (white noise generators) are devices similar to hearing aids that fit behind the ear.)
- hearing aids(Hearing aids may help in masking the tinnitus), etc
- if unresponsive to non-pharm Rx: amitriptyline : 25-75 mg/day orally given in 1-3 divided doses

sudden hearing loss
- prednisolone : 20 mg orally three times daily for 2-3 weeks, then gradually taper, or
- Intratympanic corticosteroids

onging symptoms -> surgery

2013년 6월 16일 일요일

Hydrocele / Varicocele

Hydrocele
==================



Def:
---------------------
Hydrocele is a collection of serous fluid between the layers of the membrane (tunica vaginalis) that surrounds the testis or along the spermatic cord.

Two Types:
---------------------
1. communicating - processus vaginalis communicates with the peritoneal cavity
2. non-communicating - processus vaginalis does not communicate with the peritoneal cavity, but more fluid is produced by the tunica vaginalis than it is absorbed.

Dx:
---------------------
Clinical diagnosis: transluilluminable, soft(may be tense if small) scrotal mass

If other/additional Dx is suspected ( e.g. with fever, vomitting, diarrhoea, testis not palpable etc ) -> Sonar scrotum


Rx:
---------------------
4 options:

- 1. Observation

- 2. Surgical excision of the hydrocele sac

- 3. Simple aspiration - generally unsuccessful due to rapid reaccumulation of fluid.

- 4. Sclerotherapy
(When fertility is not an issue, aspiration of the hydrocele followed by instillation of sclerosing agent into the scrotum.
Complication:
reactive orchitis/epididymitis and a higher rate of recurrence/makes open surgery more difficult due to adhesion.)

///////////
in children:

<= 2 yr : observation
>= 2 yr : surgery

In adults :
- wihtout discomfort or infection - observation
- with discomfort or infection - surgery or sclerotherapy
//////////


Varicocele
==================



Def:
--------------------
abnormal dilatation of venous pelux

Grade:
--------------------
1. small, palpable only with valsalva
2. moderate, PALPABLE on standing, non-visible
3. large, VISIBLE on gross inspection.


Dx:
--------------------
Ninety percent of varicoceles are on the left side, while approximately 10% are bilateral. A right-sided varicocele alone is rare and should raise suspicion of the presence of a retroperitoneal or pelvic compressive mass.

Scrotal Sonar

'bag of worms' appearance

///////////////
Reason why it occurs on the left commonly:
Left testicular vein drains into left renal vein.
Left renal vein's pressure is higher than testicular vein because it's compressed between aorta and superior mesenteric vein.
This leads to failure of venous valves, causing varicocele.
//////////////

Rx:
--------------------

Warn patient about possible decreased fertility.
If fertility is a concern to the pt -> semen analysis every 2 years.

Young pt (<= 20 yr) with clinically obvious hydrocele -> Surgery

Otherwise observation.

2013년 6월 13일 목요일

Rheumatoid arthritis

Rheumatoid Arthritis Criteria:
-------------------------------

Four of the following:


1 : Morning stiffness > 1 hr

3 : Affecting more than 3 joints

<--> : symmetrical

 |     : involving hands and feet

(above 4 things for 6 weeks)

R : Rheumatoid factor positive

R : Rheumatoid nodules over extensor surfaces

R : Radiographic changes

BPPV (Benign paroxysmal positional vertigo)

Background Knowledge:
-------------------------------------------------------
Semicircular canal has three components:
anterior(superior), posterior, lateral(horizontal) canal



Posterior canal BPPV — The Dix-Hallpike maneuver
--------------------------------------------------------------




Method:

- The patient's head is turned 45° towards the ear being tested.

- The head is supported, and then the patient is quickly lowered into the supine position with the head extending about 30° below the horizontal while remaining turned 45° towards the ear being tested.

- The head is held in this position and the physician checks for nystagmus.

- To complete the manoeuvre, the patient is returned to a seated position and the eyes are again observed for reversal nystagmus.

Interpretation (Positive Hallpike test):

Head is turned to the right, to test the right ear.

If the right ear is affected, nystagmus occurs as described below:
A: When the head is lowered 30 degree below the bed,
the fast phase of the nystagmus is upward , rotating toward the affected ear
B: When the patient is brought back to the sitting position,
the fast phase of the nystagmus is downward , rotating toward the affected ear


Anterior canal BPPV - The Dix-Hallpike maneuver
--------------------------------------------------------------
Method:

- same as posterior canal BPPV

Interpretation:

In positive Hallpike test, the nystagmus is downbeat and torsional(rotational), with the top of the eye torting away from the lower ear.


Treatment of Posterior or Anterior canal BPPV
--------------------------------------------------------------
Two methods: Epley maneuver and Semont maneuver



Epley maneuver
/////////////////
Place the patient in a sitting position on the end of the examination table.

Rotate the head 45° towards the affected ear, then swiftly place the patient in a supine position with the head hanging 30° below the horizontal at the end of the examining table (Dix-Hallpike position).

Observe for nystagmus and hold the position for ~30 seconds after it stops.

The head is rotated 90° towards the opposite ear while maintaining the head hanging position.

Observe for nystagmus and hold the position for ~30 seconds after it stops.

Continue then to roll the whole patient another 90° towards the unaffected side until their head is facing 180° from the original Dix-Hallpike position. This change in position should take <3 to 5 seconds.

Observe for nystagmus and hold the position for ~30 seconds after it stops.

Then have the patient sit up. Upon sitting, there should be no vertigo or nystagmus in a successful manoeuvre, because the particles will have been cleared from the posterior semicircular canal back into the utricle.

If there is not paroxysmal nystagmus or symptoms during Dix-Hallpike positioning (Steps 1, 2) then there is a high likelihood of success.
/////////////////



Semont maneuver
////////////////
Sit the patient midway along the long side of an examination table, with their legs hanging over the edge.

Rotate the head 45° towards the unaffected side. While maintaining the head rotation, swiftly place the patient's upper body in a side-lying position on the affected side, with the head resting on the examination table and now facing upwards. This may induce nystagmus and vertigo because of particle movement towards the apex of the semicircular canal. Maintain this position until the vertigo and nystagmus stop (1 to 2 minutes).

Move the patient rapidly through the sitting position of step 1 and into the opposite side-lying position while maintaining the same head rotation, so that the head is resting on the examination table and now facing downwards. A nystagmus response in the same direction would indicate that the particles are exiting the semicircular canal. The transition from step 2 to 3 relies on inertia, and therefore it must be done very quickly. Maintain this position until the vertigo and nystagmus stop (1 to 2 minutes). Slowly return the patient to the sitting position of step 1.



Lateral(Horizontal) canal BPPV - Supine head turn maneuver
--------------------------------------------------------------



The nystagmus of horizontal canal BPPV, unlike that of posterior canal BPPV, is distinctly horizontal(moving to the left and or to the right, i.e. not up and down) and changes direction with changes in head position. There is no torsional(rotational) component.

The paroxysmal direction changing nystagmus may be either geotropic or apogeotropic.

Geotropic direction-changing positional nystagmus is right beating upon turning the head to the right and then left beating when turning the head back to the left side. (geotropic nystagmus = nystagmus "towards ground")
Conversely, the apogeotropic form indicates the nystagmus is right beating with turning to the left and left beating with turning to the right. (apogeotropic nystagmus = nystagmus "away from ground")

In geotropic nystagmus,
The downward ear, on the side where the nystagmus is more intense = the affected ear.

In apogeotrpic nystagmus,
The downward ear, on the side where the nystagmus is less intense = the affected ear.

{그냥 쉽게 병변 쪽으로 nystagmus 가 더 심하게 흘겨 본다고 보면 됨}

The latency is often brief, and the duration may be 15 to 60 seconds. This nystagmus appears less apt to fatigue with repeat

positioning than in cases of posterior canal BPPV; consequently, patients are more likely to become ill with attempts to fatigue this

form of BPPV.
(There is speculation that apogeotropic direction-changing nystagmus suggests cupulolithiasis, and geotropic nystagmus

suggests canalithiasis as the mechanism.)


Treatment of Lateral(Horizontal) canal BPPV
--------------------------------------------------------------

Lempert roll maneuver
////////////////////////



Lempert 360- (Barbeque) degree roll maneuver to treat horizontal canal BPPV. When the patient's head is positioned with the affected ear down, the head is then turned quickly 90 degrees toward the unaffected side (face up). A series of 90-degree turns toward the unaffected side is then undertaken sequentially until the patient has turned 360 degrees and is back to the affected ear-down position. From there, the patient is turned to the face-up position and then brought up to the sitting position. The successive head turns can be done in 15- to 20-second intervals even when the nystagmus continues. Waiting longer does no harm, but may lead to the patient developing nausea, and the shorter interval does not appear to detract from the effectiveness of the treatment.
////////////////////////


Gufoni maneuver
////////////////////////



(1) patient seated on the examination couch with both the legs hanging out from the same side, arms held close to the body, and

hands resting on the knees
(2) patient is then made to lie down on the uninvolved lateral side with a quick lateral movement and maintained in this position for 2

minutes until the end of evoked geotropic nystagmus
(3) quick 45° rotation of the head towards the floor, position being maintained for 2 minutes
(4) slow return back to the starting position
////////////////////////


Chracteristics of BPPV:
---------------------------------
- The latency, transience, and fatigability of the nystagmus
(latency - few seconds (2~5 sec)
transience - usu. lasts less than 30 sec
fatigability - nystagmus / diziness weakens with repeted maneuver)

- Typical mixed upbeat/downbeat + torsional(rotational) nystagmus


Characteristics of Central disorder:
---------------------------------
Latency - none
duration of nystagmus - greater than 1 minute
not-fatiguing


(videos:
Post/Ant canal BPPV
http://www.youtube.com/watch?v=59EIKztATiw
http://www.youtube.com/watch?v=LsPURdtMjac
Laterl canal BPPV
http://www.youtube.com/watch?v=iOJOArGmepM
http://balancemd.net/Horizontal_Canal_BPPV.html)

2013년 6월 11일 화요일

CXR - Dilated heart







Enlarged globular cardiac silhouette with cardiothoracic ratio of 58%. Right cardiac border forms a double contour; this usually suggests left atrial dilatation, but in this case it is caused by right atrial dilatation. 

(reference: Circulation vol. 118 no. 9 e133-e135)

Subclinical Hyperthryoidism

Low TSH + Normal FT4 + Normal FT3 -> subclinical hyperthryoidism

studies lack, but hyperthyroidism treatment (antithyroid meds/radioactive iodine) probably helps against osteoporosis and cardiac arrhythmia.

Cause:

Exogenous - thyroid hormone tablet.

Endogenous -  multinodular goiter, thyroid adenoma - are the most common cause of endogenous subclinical hyperthyroidism.

Rx:

TSH < 0.1 mU/ml  -> treat the cause.

TSH 0.1~0.5

-> in elderly or high risk pt - treat the cause.

-> in low risk pt - observe. repeat blood test every 6 months.

UA/ Non-STEMI

Angina is considered to be unstable if it is prolonged (lasting more than 20 minutes), if it occurs at rest.

Unstable angina:
absence of biochemical evidence of myocardial damage
clinical findings of prolonged (>20 minutes) angina at rest

NSTEMI is distinguished from UA by the presence of elevated serum biomarkers. ST segment elevations and Q waves are absent in

both UA and NSTEMI. As a result, UA and NSTEMI are frequently indistinguishable at initial evaluation since an elevation in serum

biomarkers is usually not detectable for four to six hours after an MI, and at least 12 hours are required to detect elevations in all

patients.


DX:
----------

Cardiac biomarkers (troponin I or T, and creatine kinase-MB [CK-MB]) should be measured on presentation.

CK-MB has low sensitivity during early (<6 hours) or late (>36 hour) symptom onset and for minor damage.
CK-MB also has low specificity

Both troponin T (TnT) and troponin I (TnI) are more specific but have lower sensitivity for the very early detection of myocardial

necrosis. If the early (<6 hours from symptom onset) troponin test is normal, it should be repeated after 8 to 12 hours.
Troponin remains elevated up to 10 to 14 days after release.

ECG findings in UA/NSTEMI: normal or ST depression +- T wave inversion

A repeat ECG should be performed at 6 and 24 hours and if clinical status changes.


{즉,
Normal ECG -> repeat after 8 hrs.
Normal CK-MB, Trop I -> repeat after 8 hrs.
}

RX:
-----------

{
MONA

BS

invasive approach or non-invasive approach
}

MONA (aspirin 300 mg + clopidogrel 300 mg)
(antiplatelet continuation dose - aspirin 75 mg + clopidogrel 75 mg daily PO)
exclude use of errectile drugs (e.g.viagra) before using nitrate.

B(beta blocker)  S(statin)

Invasive approach:
-PCI/CABG plus abciximab IVI

Non-invasive approach:
-Enoxaparin sodium 1 mg/kg SC 12hrly X 7 days  plus abciximab IVI

An aggressive approach to reperfusion using PCI is best suited for patients with an elevated troponin level or a TIMI risk score ≥5 or

possibly other high-risk features. (See 'High-risk patient' below.) For patients at lower risk, approaches vary based upon hospital

protocol.

Fibrinolytic therapy is not beneficial in patients with a non-ST elevation ACS. (-> This is the difference between STEMI and Non-

STEMI) Therefore, thrombolytic therapy should NOT be administered to patients with UA or NSTEMI unless subsequent ECG

monitoring documents ST segment elevations that persist.

2013년 6월 8일 토요일

Asthma

=================

Asthma

=================

Symp:

SOB (in)
cough (물 out)
wheeze (공기 out)
inability to speak (소리 out)


Tests:

PEFR
Sats
+- ABG / CXR


Criteria:

mild: PEFR > 70% - dyspnoea only with exertion
moderate: PEFR 40~70 % - dyspnoea limits daily activity
severe: < 40 % - interferes conversation

(peadiatric crteria
PEFR is the same.
mild: talks in sentences
moderate: talks in phrases
severe: talks in words/ can't talk
)

Sat < 90 %
-> at least severe to life threatening asthma

Rx:

Oxygen

Inhaled Short-acting Beta2 agonists
Oral corticosteroid
Inhaled Anticholinergic
Magnesium

{데이빗 "배컴"
BACOM - Beta agonist, Anticholinergic, Corticosteroid, Magnesium

AA - Adrenaline, Antibiotics (adjuntive therapies)
}

///////
--mild--

-Salbutamol 2.5 ~ 5 mg nebulized every 20 min X 3

-Oral corticosteroid - prednisone 40 ~ 80 mg / day X 7 days

(
Pead dose:
Oral corticosteroid - prednisone 1mg/kg/day (max 40mg) (IV dose is the same)
)


--moderate to severe--

-Ipratropium bromide 0.5 mg nebulized in combination with salbutamol as above (every 20 min X 3)

-MgSO4 - 2 g IV over 20 min


---Life threatening ---

-IV hydrocortisone mg IVI 8 hrs (can be switched to oral as soon as possible)


-adjunct -
epinephrine: 0.01 mg/kg IMI as a single dose, if  anaphylaxis suspected
antibiotics if infection suspected ( mycoplasma penumonia most common - erythromycin 50mg/kg/day in 4 divided doses)

///////



==================

Asthma

==================

criteria:

mild:
-FEV1 >  80 %
-symptom <= 2 per wk
-night symptom <= 2 per month

(mem tip 2, 2)

moderate:
-FEV1 60~80 %
-symptom daily
-night symptom > 1 per wk

(mem tip 1, 1)

severe:
-FEV1 < 60 %



DX:

Low in both FEV1/FVC and FEV1.
( FEV1/FVC < 80 % predicted
  FEV1 < 80 % predicted )

FEV1 improves by 200 ml AND 12 % after bronchodilator.


Rx:

mild - short acting beta agnoist (e.g. salbutamol)

persistent mild - short acting beta agonist + corticosteroid inhaler

moderate - short acting beta agonist + corticosteroid inhaler + long acting beta agonist (e.g. salmeterol)

severe - short acting beta agonist + corticosteroid inhaler + long acting beta agonist (e.g. salmeterol) + oral corticosteroid

Carpal tunnel

Carpal tunnel syndrome
:Compression of median nerve

Symptoms:

{
Sensory - too little (numbness)
              - too much (tingling, pain)
Motor - weakness, clumsiness
}

Numbness (thenar eminence is spared - supplied by palmar branch which lies outside the carpal tunnel)
Tingling
Pain (in Hand and arm. Pain may radiate from ventral aspect of wrist proximally to forearm and upper arm. Maybe worse at night)
Clumsiness
Weakness of hand

Tests:
EMG
U/S wrist
MRI wrist

Differential:
c6, c7 radiculopathy
brachial plexopathy

Rx:

Splint

NSAIDs

Corticosteroid injection

Surgical release

Dementia

Dementia

majority of cases of dementia are caused by :
1.degenerative causes and by
2.vascular causes

Degenerative causes include Alzheimer's disease (the most common cause of dementia accounting for an estimated 60% of

cases), Parkinson's disease, etc.

Note: 10% to 20% of dementias are caused by potentially reversible conditions
(e.g. infections, inflammatory diseases, neoplasm, toxic insults, metabolic disorders, and trauma )

NB Differential - Delirium is an acute (hours to days), usually reversible, metabolically induced state of fluctuating consciousness.


Adjunct Therapy - antipsychotic (controversial) - haloperidol 0.5 mg bd PO

Behavioural management

-consider stopping all benzo & antipsychotic ( paradoxical aggrevation )

-Mood stabilizer: carbamazepine 100 mg bd po

-lorazepam 0.5 mg PO/IMI when required,

2013년 6월 4일 화요일

Organophosphate poisoning

Organophosphate poisoning

-Acetylcholine esterase inhibitor -> inc Ach level at the synapses

Signs/Symps:

-increased secretions: lacrimation, salivation, pulmonary edema -> crepitation
-bronchospasm -> wheeze
-pinpoint pupils
-decreased level of consciousness


Dx:

-Atropine trial: poisoned pt show little/no anticholinergic effect. (Look at heart rate (inc), skin dryness, pupil dilatation)

-plasma cholinesterase measurement

-others: ecg, bld gas, CXR

Rx:

- Resus + supportive care: IV + airway + ventilation
- Decontamination ( discard clothes, wash skin, stomach contents aspirated if airway is protected )
- Atropine:
(atropine : 2 mg intravenously initially, followed by double doses (e.g., 4 mg, 8 mg, 16 mg, etc.) every 5 minutes until secretions are controlled. Atropine requirements are extremely variable; daily doses range between 10 and 1000 mg or more.)


{간단히
눈 - constricted pupil, lacrimation
입 - salivation
폐 - pulmonary edema (crepitation), bronchospalsm ( wheeze )
심장 - bradycardia}

Paed Hx Taking

Paed Hx Taking

-Coughing
-Vomiting
-Diarrhoea

-Feeding
-Fever

-Birth
-Vaccine
-Growth

-HIV
-TB

Burn wound / Stevens-Johnson

============================
Burn
============================

classification:

1st degree
-involves epidermis
-red, painful, dry
-blanch with pressure

2nd degree
-involves epidermis + dermis
-red, painful, wet
- (+-)blisters
-blanches with pressure

3rd degree
-involves epidermis + dermis + skin appendages
-white/black, insensate, dry
-does not blanch with pressure

4th degree
-involves epidermis + dermis + skin appendages + subcutaneous tissue / tendon / bone
-white/black, insensate, dry
-does not blanch with pressure

{mem tip:
pain / blanch/ colour / dry-wet

p b c d
}

indication for admission:
-partial-thickness burns of >10% TBSA;
-face, hands, feet, genitalia, perineum, or major joints;
-electrical burns, including lightning injury;
-chemical burns;
-inhalation injury;
-burn injury in patients with pre-existing medical disorders

Rx:

topical antibiotic prophylaxis
(Silver is an excellent antiseptic and is used in burn wound care
The silver helps to prevent infection and remains active for 3 to 4 days, allowing less frequent dressing changes.)

tetanus immunisation

morphine 10 to 30 mg orally every 3-4 hours when required

Fluid resuscitation:

If burns involve >15% of the body surface, loss of capillary integrity becomes significant, requirng fluid resuscitation.
Parkland formula is often used and suggests 4 mL/kg/% burn over the first 24 hours, half in the first 8 hours, generally as lactated

Ringer's solution. Capillary integrity is typically restored at approximately 24 hours.
(Young children should receive 5% dextrose in lactated Ringer's solution (D5LR) at a maintenance rate to ensure that they do not

develop hypoglycaemia.)

infected wound -> debridement + antibiotic

circumferential burns -> escharotomy

Nutrition / physio / occupational therapy


[dose: midazolam : 0.04 mg/kg IVI
morphine: 0.1 mg/kg IVI]

{Burn description 간략히

-깊이
-넓이
-어디
-EIC (에 이 씨) - electrical ( myoglobin inc -> renal impairment, hyperkalemia -> arrhythmia),  inhalational burn, chemical // open fire,

boiling water...
}

{Burn Rx 간략히

-Fluid
-Analgesic
-Antibiotic

-Dressing (Silver dressing)
-escharotomy
}

============================
Steven-Johnson syndrome
============================

Rx:

Stop offending agent ( common causative agent: sulfonamide (bactrim), NSAIDS (therefore NSAIDs should not be used for analgesic

unless other medicines, such as opioids or paracetamol, do not work), corticosteroids, etc)

ABC (airway edema -> obstruction)

Dressing (silver dressing (e.g. silver sulfadizine) )

Analgesic (avoid NSAIDs)

Fluid (Parkland formula)

Nutrition / physio / occupational therapy

morphine sulphate : children: 0.1 mg/kg orally/intravenously every 2-4 hours when required, maximum 15 mg/kg;
adults: 7.5-10 mg orally/intravenously every 4 hours when required


adjunct:

1) glucocorticoids

advese effect: may increase risk of infection - infection is the main reason for mortality
use: it can be used in - Adults with burn (%) less than 30 %. Don't use in paed pt, or burn > 30 %.
prednisone 2 mg/kg/day not more than 7 days ( or equivalent amount of prednisolone or methylprednisolone )

2) IV immunoglobulin

2013년 6월 3일 월요일

Hepatitis B

Hep B e Ag > 3 months
-> high likelihood of chronic infection

Hep B e Ag positive
-> majority have active infection
-> it also indicates greater infectivity.

Hep B core Ab
-> indicates exposure to hepatitis B virus

Hep B surface Ag > 6 months
-> indicates chronic hepatitis B infection

Hep B DNA Qualitative assay

Window period:

[ HBsAg: neg, HBsAb: neg, HBcAb: pos]

The disappearance of HBsAg (hepatitis B surface antigen) is followed by the appearance of anti-HBs. In some patients, however,

anti-HBs may not be detectable until after a window period of several weeks to months. At this time, neither HBsAg nor anti-HBs can

be detected, the serologic diagnosis may be made by the detection of IgM antibodies against hepatitis B core antigen (IgM anti-

HBc).


Rx:

Acute Hep B - fulminant infection:
- supportive
- lamivudine +- liver transplant

Chronic
-interferon
-antiviral therapy (tenofovir, lamivudine, etc)

indication for Rx in chronic infection:
-co-infection with HIV or Hep D
-cirrhosis
-if no coinection/comorbidity:
 -HBeAg positive, HBV DNA > 20 000 IU, ALT > twice upper normal limit
 -HBeAg negative, HBV dNA > 2 000 IU, ALT > upper normal limit

Haemorrhoids

Causes of haemorrhoids:
-------------------------
The primary aetiology is believed to be excessive straining due to either chronic constipation or diarrhoea.
Other causes:an increase in intra-abdominal pressure can be caused by pregnancy or ascites;
the presence of space-occupying lesions within the pelvis

Types of haemorrhoids:
-------------------------
1) External haemorrhoids
:Haemorrhoids that are located in the distal anal canal, distal to the dentate line, and covered by sensate anoderm or skin.

2) Internal haemorrhoids
:Haemorrhoids that originate proximal to the dentate line and covered by insensate transitional epithelium

    Grade 1 - protrusion is limited to within the anal canal.

    Grade 2 - protrudes beyond the anal canal but spontaneously reduces on cessation of straining.

    Grade 3 - protrudes outside the anal canal and reduces fully on manual pressure.

    Grade 4 - protrudes outside the anal canal and is irreducible.

This grading of internal haemorrhoids is only a reflection of the degree of prolapse but is not a measure of either the disease severity or of the size of haemorrhoidal prolapse.


Rx:
--------------------------
For all grades:
 Straining or spending excessive time at stool should be discouraged.
 Constipation can be avoided by adding fibre and fluids to the diet; consuming 25 to 30 g of fibre daily .

(+- stool softeners short-term)


grade 1 haemorrhoids

 Creams and ointments are generally used for external haemorrhoids
 and suppositories are generally used for internal haemorrhoids

 hydrocortisone rectal :
 (1 to 2.5%) apply twice daily for a maximum of 5-7 days;
 25 mg (1 suppository) into the rectum twice daily for 14 days


grade 2

 rubber band ligation or sclerotherapy or infrared photocoagulation or haemorrhoid arterial ligation or stapled haemorrhoidopexy


grade 3

 rubber band ligation

grade 4

 Surgical haemorrhoidectomy


Thrombosed haemorrhoid:

Treatment of acute thrombosis of internal hemorrhoids is usually conservative.

In thrombosed external hemorrhoids, surgical evacuation of the hemorrhoid with excision of the skin overlying the thrombosed hemorrhoid can produce immediate relief. As an alternative, oral and topical analgesics, stool softeners, and sitz baths may provide adequate relief until spontaneous resolution occurs


{간략히


stool softener
누기
don't strain
dietary fiber
아파
topical analgesic

grade I : corticosteroid cream / suppository

> grade I: band ligation / haemorrhoidectomy
}

2013년 5월 31일 금요일

WRIST , DIGITAL , PENILE , FACIAL BLOCK

WRIST , DIGITAL , PENILE , FACIAL BLOCK

=================================
WRIST BLOCK
=================================

(Reference:
https://osler.ucalgary.ca/ume/proskills/NBlockWrist/NBWristArticle.htm
http://bentollenaar.com/_MM_Book/Ch.17.htm)

(Netter 461, 467, 468 참조)



Injection for the Median Nerve
-----------------------------
Find the Palmaris longus, at 1cm proximal to the distal wrist flexion crease.
[The Palmaris longus can be found as follows:
find the radial artery, roll your fingers toward the ulnar side to feel for the first tendon
(this will be the flexor carpi radialis), now roll and feel for the second tendon which will be the Palmaris longus.]
(Note that palmaris longus may be absent in some people)

Move and aim just off the radial side of the Palmaris longus (and medial to the flexor carpi radialis).
Insert the needle perpendicularly and advance slowly until a ‘pop’ through the transverse carpal ligament (aka flexor retinaculum).

Inject 3-5mL just deeper than the Palmaris longus tendon.

Inject some subcutaneously to block superficial branch of median nerve.


Injection for the Ulnar Nerve
-----------------------------

Two ways: lateral approach and volar approach (volar approach is more difficult and is omitted here)

Lateral Approach:

At the proximal palmar crease, insert the needle on the ulnar aspect of the flexor carpi ulnaris tendon.
[The flexor carpi ulnaris can be found as follows: find the ulnar artery, and roll your fingers in an ulnar direction over the first tendon

which will be the flexor carpi ulnaris.]

Advance horizontally under the tendon 1.0-1.5cm (paresthesia should be elicited to confirm proper position close to the nerve within

the thick neurovascular bundle). Alternatively, advance the needle toward the ulnar bone deep to the flexor carpi ulnaris and inject

as needle is being withdrawn.

Cutaneous nerves branch off the ulnar nerve to wrap around the wrist and supply the dorsum of the hand. Block these with a 5-10mL

SQ(subcutaneous) band of anesthetic from the lateral boarder of the flexor carpi ulnaris to the dorsal midline. Note: if the lateral

approach is used, the same injection site can be used to block these dorsal branches.


Injection for the Radial Nerve
-----------------------------

Block branches with a 5-10mL SQ band of anesthetic from the primary injection site to the dorsal midline


주의
------------------------------

Nerve 안에 주사하면 안됨. (causes intense pain)

Nerve 주위에 주사하는 것임. (causes sensation of pins and needles)


(Elicitation of Paresthesias

It is important to ascertain that the needle is making contact with the nerve rather than penetrating it, and that the injection is in

proximity to the nerve (perineural) rather than within its substance (intraneural).
The high pressures generated by a direct intraneural injection can cause hydrostatic (ischemic) injury to nerve fibers. A perineural

injection may produce a brief accentuation of the paresthesia, whereas an intraneural injection produces an intense, searing pain

that serves as a warning to immediately terminate the injection and reposition the needle.
Pain intensity and duration help differentiate between accentuation and intraneural injection.)


Local anesthetic
---------------------------------

Lignocaine(Xylocaine):
-onset: 2~5 min
-duration: 1 hr
-max dose: 3 mg /kg

Bupivacaine(Marcain):
-onset: 15 min
-duration: 4 hrs
-max dose: 2 mg /kg


=================================
DIGITAL BLOCK
=================================

http://www.youtube.com/watch?v=25kZWI_MYrg


=================================
PENILE BLOCK
=================================

Key anatomical area:
The triangular space lying deep to the fascia, bounded above by the symphysis pubis and below by the corpora cavernosa

Area to watch out:
Avoid 12 o'clock dorsum - has vessels. if penetrated can cause hematoma.



The technique involves inserting the needle until ittouches the pubic symphysis.  This gives a guide todepth.
The needle is then withdrawn and redirected to pass below the symphysis and 3-5 millimetres deeper depending on the size of the patient. It is preferable to direct it slightly laterally into the pear shaped space and then to re-insert in on the other side depositing equal volumes on each side. Avoiding the midline injection reduces the chance of penetrating the dorsal vessels of the penis and causing haematoma. If a short beveled needle the fascia may be felt as a slight resistance when it is penetrated, but in small children this is not always felt as it is thin and may offer little resistance.



(reference:
http://www.google.co.za/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&cad=rja&ved=0CDMQFjAB&url=http%3A%2F%2Fupdate.anaesthesiologists.org%2Fwp-content%2Fuploads%2F2009%2F10%2FPenile-Block.pdf&ei=dOmoUeCcLqKu7AbEzYHIDg&usg=AFQjCNGH4R1wqGV4e94fC-noyknDWV4vcQ&sig2=EH8mZAFk-afpO7MRhJsN3A
http://pgmedic.blogspot.com/2011/11/dorsal-penis-block.html)

=================================
FACIAL BLOCK
=================================


(REFERENCE:
 http://johnpaoli.com/post/459714022/facial-nerve-blocks-injection-sites-and)

2013년 5월 29일 수요일

Erythema nodosum / Behcet's disease

===================
Erythema nodosum
===================

In the majority of cases,
painful,
erythematous nodules
develop on the anterior surfaces of both legs,
that resolve without scarring over a two- to eight-week period.

Polyarthralgia, fever, and malaise frequently accompany the eruption.
erythrocyte sedimentation rate is often elevated.

antistreptolysin-O titer


Cause:
-------
streptococcal pharyngitis is the most common cause of erythema nodosum.
Erythema nodosum and hilar adenopathy: consider - sarcoidosis, TB, etc as the cause
oral contraceptives


=================
Behcet's disease
=================

clinical features:
---------------
oral ulcer / genital ulcer / erythema nodosum
uveitis / red eye

(unlike other erythema nodosum cases, Behcet's-associated lesions may ulcerate.)

Lab tests:
There is no lab test to confirm Becet's disease.
But exclude other conditions. In Becet's:
ANA is negative
RF is negative

{ 간단히

-ANA: neg
-RF: neg
}

Dx criteria:
International Study Group (ISG) criteria -
recurrent oral ulcer ( > 3 times a year ) plus one of the following:
-recurrent genital ulcer
-skin lesion (e.g. erythema nodosum)
-eye lesion (e.g. uveitis)
-positive pathergy test

(pathergy test: Pathergy is defined by a papule 2 mm or more in size developing 24 to 48 hours after oblique insertion of a 20 gauge

needle 5 mm into the skin, generally performed on the forearm.)

{ 간단히: muco- cutaneous + eye

-Oral
-Genital
-Skin
-Eye
}



Rx:
prednisone 1 mg/kg/day PO
azathioprine 2.5 mg/kg/day PO

corticosteroids can be tapered after active disease has been controlled.
immunosuppressants are continued for 1 year.

initial therapy: prednisone (40 to 60 mg PO daily) and azathioprine (50 mg PO daily). The prednisone dose is maintained at its initial

level for one month and then tapered off over three to four months. Azathioprine is increased as tolerated over four to six weeks to a

daily dose of 2.5 mg/kg.

{ 간단히

prednisone - 60 mg  for 1 month and then taper over 3 to 4 months
azathioprine - start with 50 mg. increase to 2.5 mg/kg over 1 month. continue for 1 year.
}


Complication:

CNS: impairment in - memory, speech, balance, etc
GIT: GIT ulcer, diarrhoea
Vessel: aneurysm (e.g. of major vessles including pulmonary vasculature -> hemoptysis.), large vessel arteritis, venous thrombosis


2013년 5월 25일 토요일

CCF Rx

CCF

Acute:

-three catagories
1)hemodynamically stable
2) hypotensive
3) hypertensive

in all types:

-Oxygen + supportive therapy

----
Hemodynamically stable:

Nitroglycerine
Furosemide
Asprin + revascularization if indicated
----

----
Hypotensive:

Inotropes ( sys bp 100~85: dobutamine, sys bp <  85: dopamine or noradrenaline - memtip: do BETTER(buta) mine - BP is "better" )
Asprin + revascularization if indicated
----

----
Hypertensive:

Nitroglycerine
Beta blocker
----

Mem tip:
furosemide, inotrope, b blocker.  - unique to each cases
shared by 2 cases - nitroglycerine, aspirin


Chronic:

-ACEI
-Beta blocker

optional: digoxin, furosemide

Breast mass

Triple test
1) physical exam
2) imaging
3) cytology/histology

physical exam

///////

note and document:

breast symmetry
skin changes (peau d'orange, retraction)
nipple inversion, discharge
tenderness.

mass (size, border, mobility, consistency, location, etc)

///////



Imaging

////////

if age > 30 -> mammogram

if age < 30 -> sonar

////////


Needle aspiration / Core needle biopsy

////////

Do needle aspiration
-> mass is cyst (fluid is aspirated)
--> if fluid is bloody -> refer to surgeon
--> if fluid is non-bloody AND seen to be completely decompressed on U/S -> follw up
--> if fluid is non-bloody AND the mass is not completely decompressed on U/S -> do core needle biopsy

-> mass is solid (fluid is not aspirated) -> do core needle biopsy

///////

2013년 5월 22일 수요일

ESSENTIAL ANESTHETIC DRUGS

working out expected weight:
<= 9 yr:  kg = 9 + ageX2
> 9 yr :  kg = ageX3

phenylephrine 1~2 ug/kg, usually  50 ug bolus,  infusion: 0.1 ug/kg/min then titrate
adrenaline  0.1~1 ug/kg/min,  10 ug/kg bolus
ephedrine  0.1~0.2 mg/kg,  usually 5 mg bolus

propofol  2~2.5mg/kg  bolus
ketamine  2 mg/kg bolus
etomidate  0.1~0.2 mg/kg  bolus

morphine  100 ug~ 1 mg /kg - onset: 20 min, duration: 4 hrs
alfentanyl  10 ~ 20 ug/kg
fentanyl 1~ 3 ug/kg - onset: 2 min, duration: 20 min
sufentanyl  0.1 ug~ 0.3 ug /kg
remifentanyl 0.1~1 ug/kg/min

naloxone  6 ug /kg  (usually 0.4 mg)

suxamethonium  1~2 mg/kg
atracurium  0.5 mg/kg
rocuronium  0.4 ~ 1.2 mg/kg

neostigmine 40 ug/kg (usually 2.5 mg bolus)
atropine 20 ug /kg  (usually 0.5 mg bolus)
glycopyrrolate 10 ug/kg (usually 0.4 mg bolus)

2013년 5월 21일 화요일

DM

Diabetes
----------

Dx
---
HbA1C > 6.5 %


Fasting (> 8hr) glucose >7 mmol/L


Random glucose >11 mmol/L

Oral glucose tolerance test >11 mmol/L
(give 75 g oral glucose. measure level after 2 hrs)

---
Other exam:
Kidney function (albuminuria & GFR): Random spot urine Albumin/Creat ratio. GFR from Serum Creat.
Heart: ECG, lipogram
Eye: fundoscopy
Foot: foot exam.


(Blood tests to order: glucose, HbA1c, Cr, Lipogram)


Rx
---

Life style - exercise, lose weight, eat vegetable, stop smoking





1. BP control:

ACEI /ARB -> THIAZIDE -> Ca blocker -> Beta blocker  (에이스 두 꺼 비 - ace thi ca be)

(The American Diabetes Association recommends the following step therapy: ACE inhibitor or angiotenin-II receptor blocker as the

initial agent; to add thiazide if not well controlled; then if needed add calcium channel blocker; then if needed add beta-blocker.)

2. lipid control

simvastatin 40mg dly PO

+- 3. antiplatelet

aspirin 75 mg dly PO


Insulin therapy can be initial therapy (i.e. skip oral hypoglycemic trial) when fasting glucose > 16.5 mmol/L or random glucose > 19.5

mmol/L.


2 types of insulin:

1. bolus (ultra fast and fast acting insulin)
2. basal (intermediate and long acting insulin) - given before meal.


insulin type according to duration:

-ultra fast acting -> 방금 먹은 끼니에 작용 (given 5 min before meal or even immediatelty after meals)

-fast acting -> 다음 끼니 혈당을 잡음 (given 30 min before meal - due to slower onset than ultra fast insulin)

-intermediate acting -> 두끼 앞 혈당을 잡음

-long acting 

(ultra-fast & long-acting insulins are more expensive.)

insulin trade name examples:
e.g.) fast : actrapid,   intermediate: protaphane,    biphasic: actraphane (actrpaid + protaphane in 30:70)
        fast : humalin R,    intermediate: humalin N,    biphaisc: humalin  30/70  (humalin R + humalin N in 30:70)
참고: NPH = isophane insulin


4 strategies to give insulin:

1) basal alone (long acting)
2) basal + bolus
3) basal + bolus (intermediate + fasting acting)
4) insulin in combination with oral agent


insulin 의 투여 시기:

-아침, 점심, 저녁, 취침전 - 넷중에 하나
-fast 는 끼니(아침, 점심, 저녁)때에
-Intermediate, long acting 은 아침이나 취침전에 투여




initiation and adjustment of insulin in typeII DM:

---
Step1:

bed time long acting insulin(glargine(Lantus) better than determir(Levemir))
dose: 10 U or 0.2 U/kg

increase dose by 2 U every 3 days until fasting glucose lies in target range.
(increase by 4 U every 3 days if fasting glucose > 10 mmol/L)

If hypoglycemia:
reduce dose by 4 U or 10 % (whichever is greater)

Step2:

check HbA1c in 3 months:
if < 7 -> good. check again in 3 months.

if > 7: then

check glucose at: pre-lunch, pre-dinner, pre-bed time:
--
high pre-lunch glucose
-> add rapid acting insulin at breakfast

high pre-dinner glucose
-> add rapid acting insulin at lunch
OR - add intermediate acting(NPH) at breakfast

high pre-bed time glucose
-> add rapid acting insulin at dinner
< ?? OR - add intermediate acting(NPH) at lunch ? -> not mentioned. Intermediate is not used during lunch?? >

how much to add?
-usually 4 U.
and adjust by 2 U every 3 days until glucose lies within range.
--

---


Type 1 DM


"conventional insulin therapy" : single or two injections per day
"intensive insulin therapy": three or more injections per day (now considered standard therapy for type 1 DM) provides more

physiologic profile of insulin.


total daily insulin dose = 0.2~0.4 U / kg

one half of this total is given as basal insulin using either:
-long acting insulin (either in the morning or at bedtime.)  or
-intermediate acting insulin (two-thirds of the half of the total given in the morning, one third given at night)
(lunch bolus may be omitted if twice daily intermediate acting insulin is used)

remaining half of the total is distributed over 3 meals, using fast acting insulin. (maybe adjusted depending on size of the meal,

glucose level)

storage of insulin
-in cool place. Don't expose to direct sunlight.
-unopend, regrigerated insulin can last until expiry date.
-all types of unopend insulin can be left in room temperature ( < 30 degree C) and still maintain potency for 28 days.
-Once opened, the vials (whether refrigerated or kept at room temperature) should be discarded after 28 days.
-pens and cartridges should be stored at room temperature and discarded within the following periods:
mistures of insulin ( 70/30.. etc) : 10 days
insulin suspensions ( NPH ) : 14 days
Rapid acting insulin (Humalog, etc) : 28 days



Gesetational diabetes
def: glucose intolerance with onset and first recognition during pregnancy.

Dx:

75g oral glucose test after overnight fasting of 8hrs

Fasting level > 5 mmol/L
@ 1 hr level > 10 mmol/L
@ 2 hr level > 8.5. mmol/L

Dx made when any of the above values are exceeded.


Rx:
insulin therapy requires highly individualized titration.

In isolated fasting hyperglycemia:
-Start with 10 U intermediate acting insulin at bed time then titrate.

In post-prandial hyperglycemia:
-Start with follwing:
work out total dose with 0.7 U / kg
give two-thirds of the total in the morning and one-third before supper.
morning dose consists of two-third intermediate acting insulin and one-third fast acting insulin.
evening dose consists of one-half intermediate acting insulin and one-half fast acting insulin.




High glucose in the morning:
-can be either one of the two:
1) Somogyi phenomenon -> hypoglycemia while sleeping -> counter regulatory hormone secretion -> hyperglycemia in the morning
therefore, Somogyi needs decrease in insulin dose.
2) Dawn phenomenon -> increase insulin dose

Somogyi -> 3 am glucose is low
Dawn -> 3 am glucose is high

2013년 5월 19일 일요일

Red eyes

=================================

Eye drops/ointment

Ofloxacin ophthalmic 0.3 % 4 times a day * 7 days (or till 1 more day after the eye heals)

Conjunctival infection:
Drops - 1 drop every 4 hrs (or 4 times a day while awake)
Ointment - 3 times a day into conjunctival sac(space between cornea and palpebral and ocular conjunctiva)

Corneal infections require more frequent instillation of drops - every 30 to 60 min.

The volume of conjunctival sac is less that that of one drop. So it is wasteful to use more than 1 drop at a time.
If two or more drops are required to be instilled, allow 5 min before giving the next drop.

Don't squeeze the eyelid closed after instillation -> drops leak out of conjunctival sac.


==================================

Danger of using steroid eye drops:

- aggrevate infection
1. unrecognized herpes simplex corneal ulceration may be aggrevated leading to corneal
perforation. - never use ocular steroids in red eye with keratitis unless slit lamp and fluorescein exam have excluded hepes simplex infection.

2. fungal or bacterial infection.

---
3. raised intraocular pressure / steroid induced glaucoma

4. cataract (with chronic use > 1yr)


CGI - cataract, glaucoma, Infection

My conclusion: stay away from ophthalmic steroid. Rather leave it to specialist.


====================================

PT WITH RED EYES

-before making Dx of conjunctivitis exclude 3 conditions: keratitis(def: inflammation of the transparent cornea - mostly infectious), iritis, glaucoma(acute angle closure). These should be referred urgently.

(It's actually 5 conditions that needs to be excluded, with the below two conditions added:
- hypopyon (def: pus in the anterior chamber of the eye)
- hyphema (def: blood in the anterior chamber of the eye)
But both seem to be quite obvious on presentation..
Let's focus on the above three)


Q's to ask pt:
---
-"Can you see well?" -decreased visual acuity is a warning sign.

-"Are you sensitive to bright light?" - photophobia can be present in keratitis, iritis, glaucoma but not in conjunctivitis.

-"Did something get into your eye?" - Hx of trauma

-"Are you wearing contact lenses?" - Contact lens wear increases suspicion of keratitis

-"Can you open your eyes spontaneously and keep it open?" - objective foreign body sensation (objective foreign body sensation - pt unable to spontaneously open the eye or keep the eye open.-> suggests corneal abrasion or foreign body.
subjective foreign body sensation - "like sand in my eyes", "grittiness" -> suggests allergy, viral conjunctivitis, dry eyes. Usually no need for referral.)

-"Do you have headache, nausea, vomitting?" - suggests angle closure glaucoma
---




Helpful examination - vision / pupil/corneal opacity / pattern of redness
---
VISION
-Measuring vision in triage setting:
 It is not important to determine exactly whether the vision is 20/30 or 20/40 at 12 or 14 inches, but rather to document visual acuity in crude categories: reading vision (small print versus large print); form vision only (hand motions or count fingers); or light perception.

The fundus examination is typically not helpful in the differential diagnosis of the red eye.
( Although the pupil is midsize in angle-closure glaucoma, the fundus examination becomes increasingly difficult to perform.)

PUPIL/CORNEA
-Keratitis: white spot on cornea. spot stains with fluorescein
-Iritis: mitotic pupil
-Glaucoma(acute angle): fixed, mid-dilated pupil

PATTERN OF REDNESS
diffuse injection suggests conjunctivitis
ciliary flush (a type of injection where redness is most prounounced in a ring around limbus. the limbus is the transitional zone between cornea and sclera) suggests keratitis, iritis or angle closure glaucoma.
---

-Keratitis is characterized by : corneal opacity, decreased vision, photophobia, extremely painful eye.

-Pts with bacterial conjunctivitis should respond to therapy in 1 to 2 days with decrease in discharge, redness, irritiation. Pts who do not respond needs to be referred to an ophthalmologist.

Glaucoma

Glaucoma

2 types:

- Open angle glaucoma
- Angle closure glaucoma

Open angle
-mostly asymptomatic.
-progressive visual FIELD loss
-no pain

Angle closure
-painful eye, headache,
-Red eye (The pain of angle closure is a dull ache that is more likely reported as unilateral headache rather than eye pain.)
-seeing halos around lights
-nausea, vomitting
-Migraine 과 헷갈릴 수 있음.

<nausea, vomitting headache>
<red painful eye with halo>

Glaucoma DX:

안압 >= 21 mmHg
두눈의 안압차 >= 5 mmHg

Cup-Disc ratio >= 0.6

RX:

Angle closure:
응급:
- 0.5 % timolol (b blocker)
- 1 % aproclonidine (alpha agonist)
- 2 % pilocarpine (cholinergic)

One drop of the each of the above into the eye.

+- acetazolamide po or iv

when acute attack is over: iridotomy


MEM TIP:
<팀, 앞으로 파일로 정리해 - 에이씨>
timolol, apraclonidine, pilocarpine, acetazolamide

2013년 5월 18일 토요일

Anaphylaxis

Anaphylaxis

:life-threatening allergic reaction.

Rx:
-----------------------------------------

-Epinephrine IMI: (on anterolateral thigh rather than deltoid or buttock)
(epinephrine 1:1000 -> 1mg/ml)
Adult: 0.3 ~ 0.5 mg IMI every 5~15 min
Child: 0.01 mg/kg <max 0.3 mg>
(add 1ml of 1:1000 epinephrine to 9 ml sterile water then give 0.1 ml /kg of the mixed solution)

-IV normal saline

+- intubation / cricothyroidotomy

-Inhaled beta-2 agonist. Adult: sabultamol inhaled  5 mg every 20 min.


Adjunct therapy - Antihistamine & corticosteroids
-------------------------------------------

Antihistamines relieve itching & hives but has no effect on severe symptoms such as
airway obstruction and shock.
H1 and H2 antihistamine in combination are more effective in palliating the skin allergy.

( diphenhydrajmine 1 mg/kg IM/IVI  Adult: 50 mg
ranitidine 1 mg/kg IVI over 5 min Adult: 50 mg )


Corticosteroids have slow onset of action. It has no effect for 4 to 6 hrs even when given IVI.
Used as preventative treatment after stabilization.

(predisolone 1 mg/kg/day orally)

2013년 5월 17일 금요일

Acute MI

Acute Myocardial infarction


MONA
--------
morphine 2 mg every 5 minutes IVI  (upto 15 mg)
oxygen 100%
nitrate (glyceryl trinitrate) (e.g. Angised) 0.5 mg every 5 minutes (upto X 3)
aspirin 300 mg oral


B S
---------
betablocker - metoprolol 25 mg PO
Statin - atorvastatin 80 mg PO



REPERFUSION STRATEGY
------------------------
PCI / Fibrinolysis

PCI can be done upto 36 hrs after the onset of symptoms. - ideally should be done within 90 min after presentation.

Fibrinolysis can be done if PCI can't be done within 90 min after presentation, symptoms < 12 hrs, no contraindication (e.g. Hx of intracranial hemorrhage, stroke within last 3 months, head injury within last 3 months)

Antiplatelet therapy (in addition to aspirin)
-------------------------------------
Clopidogrel 300 mg

Anticoagulant therapy
--------------------
Enoxaparin 30mg IV loading then 1 mg/kg bd SC


mem tip:
MONO
B S
-> 모(노)비스 <농구팀 이름>
reperfusion strategy
antiplatelet, anticoagulation

2013년 5월 16일 목요일

Cardiomyopathy

Definition:
"A myocardial disorder in which the heart muscle is structurally and functionally abnormal in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to explain the observed myocardial abnormality"

즉,
- 심장근육의 병.
- 허혈, 판만, 고혈압에 의한 질환이 아님. (predominantly idiopathic/ genetic/toxin)

Three main types:
1. Hypertrophic cardiomyopathy
2. Dilated cardiomyopathy
3. Restrictive cardiomyopathy

--------------------------
Hypertrophic cardiomyopathy
--------------------------

Def:
genetic disorder characterized by
left ventricular hypertrophy (LVH)
without identifiable cause

-most common cause of sudden cardiac death in young people

Classification:
classifed into 1. obstructive and 2. non obstructive
based on left ventricular outflow tract obstruction. (as seen on echo)

Dx:
Hx of unexplained syncope
Family Hx of sudden death

Rx:
All pt should refrain from high-intensity competitive sports.

Pt at risk of sudden cardiac death:
(i.e. ventricular tachy on Holter monitoring, prior cardiac arrest)
-> ICD (implantable cardiverter defibrillator) placement


Asymptomatic pt:
-> no treatment

Symptomatic pt:

-pt with systolic dysfunction / end-stage heart failure:
--> standard heart failure therapy ( B blocker, ACEI/ARB, digoxin, +- diuretic(cautiously) )

-pt with preserved systolic function:
in obstructive type:
--> B blocker, disopyramide, surgery
in non-obstructive type
--> B blocker, verapamil (don't use disopyramide)

2013년 5월 15일 수요일

Atiral fibrillation

Atrial fibrillation

three pillars of therapy:

1. rate control (slow it down)

2. anticoagulation

3. rhythm control (restoration of sinus rhythm)

Q's to ask:

1. is pt stable? or unstable?

2. (if stable,) is pt symptomatic or asymptomatic?

3. is there a thrombus or no thrombus (on trans-esophageal echo<TEE>)

Hemodynamically unstable AF (hypotension, SOB, chest pain)

-> DC cardioversion under short general anesthesia

if there's thrombus on TEE:

Heparin + warfarin (stop Heparin once INR 2-3) for 4 weeks before cardioversion.

Heparin + warfarin (stop Heparin once INR 2-3) for 4 weeks or more after cardioversion.

if there's no thrombus on TEE

AND:

-----

Symptomatic for < 48 hrs:

if low thromboembolic risk

-> DC cardioversion or pharmacological cardioversion

if high thromboembolic risk

-> Heparin before cardioversion.

Heparin + warfarin (stop Heparin once INR 2-3) till 4 weeks after cardioversion

------

Symptomatic for > 48 hrs:

if low thromboembolic risk

-> Heparin (aPTT of 45-60 sec) before cardioversion.

long term aspirin after cardioversion

if high thromboembolic risk

-> Heparin + warfarin (stop Heparin once INR 2-3) for 4 weeks before cardioversion.

Heparin + warfarin (stop Heparin once INR 2-3) for 4 weeks or more after cardioversion.

--------

Asymptomatic:

if low thromboembolic risk

-> rate control & observe (usu. spontaneously revert to sinus rhythm in 24hrs)

-> if not recovered spontaneously  then cardioversion.

if high thromboembolic risk

-> anticoagulation & rate control for 4 wks before cardioversion

-> anticoagulation for 4 wks after cardioversion.

Mem Tip:

- thromboembolic risk = 0.5 점

- > 48 hrs = 0.5 점

합계가 0.5 점 인 경우-> heparin before cardioversion. anticoagulation for 4 wks after cardioversion

합계가 1 점 인 경우-> heparin + warfarin for 4 wks before and 4 wks after cardioversion



All pt get rate control:

if  no heart failure -> b blocker (metoprolol, esmolol) and/or CCB (diltiazem, verapamil)
if  heart failure -> amiodarone or digoxin